Welcome to opentiva’s documentation!

opentiva is a free and open-source python module that simulates target controlled infusions by using mathematical models relating to the pharmacokinetic and pharmacodynamic compartment models of drugs used in anaesthetic practice.

Contents

Features

  • Plasma and effect site targeting

  • One, two and three compartment modelling

  • Built in Pk/Pd models from a range of drugs

  • Tpeak \(k_{e0}\) calcuation

  • User defined infusions

  • Optional k20 elimination in two compartment modelling

  • Customize a range of properties relating to the targetting and maintenance methods

Installation

Install opentiva by running:

pip install opentiva

Contribute

  • Issue Tracker: github.com/opentiva/opentiva/issues

  • Source Code: github.com/opentiva/opentiva

Support

If you are having issues, please let us know via github or opentiva@jpselby.co.uk.

Disclaimer

opentiva is for informational, research and educational purposes only. The pharmacokinetic/ pharmacodynamics are all obtained from medical literature and infusions resulting from these can vary widely. The user assumes all risks from the use of this application for clinical purposes.

License

The project is licensed under the MIT license.