Drug Models

Attributes

The drug models all share the same availiable attributes shown below. These can be returned by interacting with the model object.

import opentiva.remifentanil as remifentanil

sex = 0  # male
age = 30  # years
weight = 70  # kg
height = 170  # cm

remifentanil_minto = remifentanil.Minto(sex=sex, age=age,
                                        weight=weight, height=height)

print(remifentanil_minto.compartments)
    # Number of compartments that the model uses
print(remifentanil_minto.k12)
    # Equilibrium rate constant from compartment 1 to 2
print(remifentanil_minto.ke0)
    # Effect compartment equilibrium rate constant

Parameter	Type	Description
compartments	int	number of compartments to model; 1, 2 or 3
concentration_unit	str	drug concentration unit
target_unit	str	target concentration unit
age_lower	int	lower age limit of model; -1 if no limit
age_upper	int	upper age limit of model; -1 if no limit
weight_lower	int	lower weight limit of model; -1 if no limit
weight_upper	int	upper weight limit of model; -1 if no limit
pmid	str	Pubmed ID of model’s reference
doi	str	Digital Object Identifier (DOI) of model’s reference
warning	str	Warnings relating to non-validated anthropometric values
v1	float	volume of central compartment (litres)
k10	float	equilibrium rate constant from compartment 1 to 0 (/min)
k12	float	equilibrium rate constant from compartment 1 to 2 (/min)
k13	float	equilibrium rate constant from compartment 1 to 3 (/min)
k21	float	equilibrium rate constant from compartment 2 to 1 (/min)
k31	float	equilibrium rate constant from compartment 3 to 1 (/min)
ke0	float	effect compartment equilibrium rate constant (/min)

Hypnotics

• Dexmedetomidine

  • Dyck

  • Hannivoort

  • PerezGuille

  • Rolle

• Etomidate

  • Kaneda

  • Lin

• Ketamine

  • Clements250

  • Domino

  • Herd

  • Hijazi

  • Hornik

  • Klamp

• Midazolam

  • Albrecht

• Propofol

  • Eleveld (no opiates)

  • Eleveld (opiates)

  • Kataria

  • Marsh Diprifusor

  • Marsh Modified

  • Paedfusor

  • Schnider

  • Schuttler

  • Short

• Remimazolam

  • Schmith

  • Schuttler

• Thiopental

  • Stanski

Opioids

• Alfentanil

  • Maitre

  • Goresky

  • Scott

• Fentanyl

  • Ginsberg

  • Scott

  • Shafer

  • ShaferW80

• Morphine

  • Sarton

• Remifentanil

  • Eleveld

  • Kim

  • Minto

  • Rigby-Jones

• Sufentanil

  • Gepts

  • Greely

Neuromuscular blockers

• Atracurium

  • Fisher

  • Marathe

• Cisatracurium

  • Bergeron

  • Imbeault

  • Tran

• Rocuronium

  • Kleijn Sevo

  • Kleijn TIVA

  • Wierda

  • Woloszczuk

• Vecuroniumg

  • Caldwell

  • Wierda